”A First Course in Pharmacokinetics and Biopharmaceutics”    

David Bourne, Ph.D.

Índice

1. Introduction to Course

2. Background Material

3. Pharmacokinetic Introduction

4. One Compartment I.V. Bolus

5. Analysis of Urine Data

6. Intravenous Infusion  

7. Routes of Drug Administration  

8. Pharmacokinetics of Oral Administration

9. Calculation of Bioavailability Parameters

10. Bioavailability Studies

11. Physiological Factors Affecting Oral Absorption

12. Physical-Chemical Factors Affecting Oral Absorption

13. Formulation Factors

14. Multiple IV Bolus Dose Administration

          Single dose summary

          Multiple IV bolus

15. Multiple Oral Dose Administration

16. Routes of Excretion

          Renal excretion

          Hemodialysis

          Biliary excretion

          Pulmonary excretion

          Salivary excretion

          Renal disease considerations

17. Metabolism  

18. Drug Distribution

19. Multi-Compartment Pharmacokinetic Models

           Intravenous administration

          Oral administration

          Non Compartmental Analysis

20. Non-Linear Pharmacokinetic Models  

21. Clinical Applications of Pharmacokinetics

          Therapeutic drug monitoring

          Pediatric considerations

          Geriatric considerations

22. Laboratory Assignments