”Introdution of Pharmacokinetics” (PEOI)         aceder

Conteúdos

Este curso é uma introdução à farmacocinética. Oferece uma visão global dos parâmetros farmacocinéticos e suas aplicações na prática clínica.

Artigo 1

• A Standard Weight Descriptor for Dose Adjustment in the Obese Patient          entrar

          Stephen B. Duffull, Michael J. Dooley, Bruce Green, Susan G. Poole and Carl M.J. Kirkpatrick

          (Clin Pharmacokinet 2004; 43 (15): 1167-1178)

Artigo 2

• Prescribing in renal disease          entrar

          Faull & L Lee

          (Australian Prescriber 2007; 30(1): 17-20)

Artigo 3

• Back to basics: pharmacokinetics      entrar

          Alison Thomson

          (The Pharmaceutical Journal 2004; 272:769-771)

Artigo 4

• Why do therapeutic drug monitoring       entrar

          Alison Thomson

          (The Pharmaceutical Journal 2004; 273: 153-156)

 Artigo 5

• Variability in drug dosage requirements       entrar

          Alison Thomson

          (The Pharmaceutical Journal 2004; 272: 806-808)

Clinical Practice Guidelines and Clinical Practice Recommendations
2006 Updates
Hemodialysis Adequacy
Peritoneal Dialysis Adequacy
Vascular Access                                          

National Kidney Foundation                                   entrar

CLINICAL PRACTICE GUIDELINES FOR HEMODIALYSIS ADEQUACY, UPDATE 2006

• Clinical Practice Guidelines for Hemodialysis Adequacy (Initiation of Dialysis, Methods for Measuring and Expressing the Hemodialysis Dose, Methods for Postdialysis Blood Sampling, Minimally Adequate Hemodialysis, Control of Volume and Blood Pressure, Preservation of Residual Kidney Function, Quality Improvement Programs, Pediatric Hemodialysis Prescription and Adequacy)

• Clinical Practice Recommendations for Hemodialysis Adequacy (Initiation of Dialysis, Methods for Measuring and Expressing the Hemodialysis Dose, Minimally Adequate Hemodialysis, Dialyzer Membranes and Reuse, Preservation of Residual Kidney Function)

CLINICAL PRACTICE GUIDELINES FOR PERITONEAL DIALYSIS ADEQUACY, UPDATE 2006

• Clinical Practice Guidelines for Peritoneal Dialysis Adequacy (Initiation of Dialysis, Peritoneal Dialysis Solute Clearance Targets and Measurements, Preservation of Residual Kidney Function, Maintenance of Euvolemia, Quality Improvement Programs, Pediatric Peritoneal Dialysis)

• Clinical Practice Recommendations for Peritoneal Dialysis Adequacy (Initiation of Dialysis, Peritoneal Dialysis Prescription Targets and Measurements, Recommended Laboratory Measurements for Peritoneal Membrane Function and Ultrafiltration Volume, Writing the Peritoneal Dialysis Prescription, Pediatric Peritoneal Dialysis)

CLINICAL PRACTICE GUIDELINES FOR VASCULAR ACCESS, UPDATE 2006

• Clinical Practice Guidelines for Vascular Access (Patient Preparation for Permanent Hemodialysis Access, Selection and Placement of Hemodialysis Access, Cannulation of Fistulae and Grafts and Accession of Hemodialysis Catheters and Port Catheter Systems, Detection of Access Dysfunction: Monitoring, Surveillance, and Diagnostic Testing, Treatment of Fistula Complications, Treatment of Arteriovenous Graft Complications, Prevention and Treatment of Catheter and Port Complications, Clinical Outcome Goals)

• Clinical Practice Recommendations for Vascular Access (Patient Preparation for Permanent Hemodialysis Access, Selection and Placement of Hemodialysis Access, Cannulation of Fistulae and Grafts and Accession of Dialysis Catheters and Ports, Detection of Access Dysfunction: Monitoring, Surveillance, and Diagnostic Testing, Treatment of Fistula Complications, Prevention and Treatment of Catheter and Port Complications, Vascular Access in Pediatric Patients)

Capítulo 1

• Clearance

          Australian Prescriber 1988: 11(1) 12-13

Capítulo 2

• Volume of Distribution

          Australian Prescriber 1988: 11(2) 36-37

Capítulo 3

• Half-life

          Australian Prescriber 1988: 11(3) 57-59

Capítulo 4

• How drugs are cleared by the liver

         Australian Prescriber 1990: 13(4) 88-89

Capítulo 5

• Bioavailability and first pass clearance

          Australian Prescriber 1991: 14(1) 14-16

Capítulo 6

• Predicting drug interactions and the effects of disease states for metabolised drugs

          Australian Prescriber 1991: 14(3) 57-59

Capítulo 7

• Clearance of drugs by the kidneys

          Australian Prescriber 1992: 15(1) 16-19

Capítulo 8

• Drug protein binding

         Australian Prescriber 1992: 15(3) 56-57

Capítulo 9

• Non-linear pharmacokinetics

         Australian Prescriber 1994: 17(2) 36-38

Capítulo 10

• Pharmacodynamics - the concentration-effect relationship

         Australian Prescriber 1995: 18(4) 102-104

Capítulo 11

• Designing dose regimens

          Aust Prescr 1996;19:76-8

Capítulo 12

• Therapeutic drug monitoring

          Aust Prescr 1997;20:9-11

Farmacocinética clínica     entrar

M.V. Calvo, M.J. García, J. Martínez, M.M. Fernández

”Clinical Methods - The History, Physical and Laboratory Examinations”        entrar

Third Edition / H. Kenneth Walker, W. Dallas Hall, J. Willis Hurst / Butterworths

Índice

I. Introduction 

II. The Cardiovascular System 

III. The Pulmonary System 

IV. The Neurologic System

V. The Autonomic Nervous System

VI. The Gastrointestinal System 

VII. The Skin and Appendages 

VIII. The Eye

IX. The Ear, Nose, Mouth, and Throat

X. The Endocrine System

XI. The Hematopoietic System

XII. The Musculoskeletal System

XIII. Female Genitalia and Breasts

XIV. The Genitourinary System 

XV. The Psychiatric System

XVI. The General Examination

XVII. Special Patient Groups

Introduction                                entrar

Chapter 1. Ethical Considerations

Chapter 2. Good Clinical Practice

Chapter 3. Assessment of Endpoints: Kinetics and/or Dynamics

Chapter 4. Pharmacogenetics and Pharmacogenomics

Chapter 5. Paediatric Drug Research

Chapter 6. Phase I (human Pharmacology)

Chapter 7. Follow-Up of Drugs After Market Entry

Chapter 8. Bioavailability and Bioequivalence

Chapter 9. Pharmacoeconomics and Economic Evaluation of Drug Therapies

Chapter 10. Drug Utilization

Pharmacological Research in Cardiovascular Disorders

Chapter 11. Hypertensive Vascular Disease

Chapter 12. Lipid Lowering Agents

Chapter 13. Anti-atherosclerotic Drugs

Chapter 14. Heart Failure

Chapter 15. Arrhythmias

Pharmacological Research in Neurologic Disorders

Chapter 16. Epilepsies and Convulsive Disorders

Chapter 17. Headache Disorders

Chapter 18. Alzheimer’s Disease and Other Dementias

Chapter 19. Parkinson’s Disease and Other Extrapyramidal Disorders

Chapter 20. Multiple Sclerosis and Other Demyelinating Diseases

Pharmacological Research in Mental Disorders

Chapter 21. Mood Disorders

Chapter 22. Anxiety Disorders

Chapter 23. Schizophrenic Disorders

Chapter 24. Alcoholism and Nicotine Addiction

Pharmacological Reasearch in Joint Disorders

Chapter 25. Osteoarthritis / arthrosis Short Term Studies

Chapter 26. Osteoarthritis / arthrosis Long Term Studies

Chapter 27. Rheumatoid Arthritis

Pharmacological Research in Other Disorders

Chapter 28.  Neoplastic Diseases

Chapter 29. Analgesic Drugs for Cancer Pain Management

Chapter 30. Drugs Used in Osteoporosis

  ”A First Course in Pharmacokinetics and Biopharmaceutics”    

David Bourne, Ph.D.

Índice

1. Introduction to Course

2. Background Material

3. Pharmacokinetic Introduction

4. One Compartment I.V. Bolus

5. Analysis of Urine Data

6. Intravenous Infusion  

7. Routes of Drug Administration  

8. Pharmacokinetics of Oral Administration

9. Calculation of Bioavailability Parameters

10. Bioavailability Studies

11. Physiological Factors Affecting Oral Absorption

12. Physical-Chemical Factors Affecting Oral Absorption

13. Formulation Factors

14. Multiple IV Bolus Dose Administration

          Single dose summary

          Multiple IV bolus

15. Multiple Oral Dose Administration

16. Routes of Excretion

          Renal excretion

          Hemodialysis

          Biliary excretion

          Pulmonary excretion

          Salivary excretion

          Renal disease considerations

17. Metabolism  

18. Drug Distribution

19. Multi-Compartment Pharmacokinetic Models

           Intravenous administration

          Oral administration

          Non Compartmental Analysis

20. Non-Linear Pharmacokinetic Models  

21. Clinical Applications of Pharmacokinetics

          Therapeutic drug monitoring

          Pediatric considerations

          Geriatric considerations

22. Laboratory Assignments

Artigo 1

• The Relationship Among Pharmacokinetic Parameters: Effects of Altered Kinetics on the Drug Plasma Concentration-Time Profiles          entrar

          Reza Mehvar

          (American Journal of Pharmaceutical Education 2004; 68 (2) Article 36)